Structure of PDB 7eld Chain A Binding Site BS01

Receptor Information
>7eld Chain A (length=1137) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRYQLDVLEQAKAKNTIAFLETGAGKTLIAILLIKSVHKDLMSQNRKMLS
VFLVPKVPLVYQQAEVIRNQTCFQVGHYCGEMGQDFWDSRRWQREFESKQ
VLVMTAQILLNILRHSIIRMETIDLLILDECHHAVKKHPYSLVMSEFYHT
TPKDKRPAIFGMTASPVNLKGVSSQVDCAIKIRNLETKLDSTVCTIKDRK
ELEKHVPMPSEIVVEYDKAATMWSLHETIKQMIAAVEEAAQASSGAANLI
HKLRAINYTLAELGQWCAYKVGQSFLSALQSDERVNFQVDVKFQESYLSE
VVSLLQCELLEGASLIKLLLKYQHTADFRAIVFVERVVAALVLPKVFAEL
PSLSFIRCASMIGHNNSQEMKSSQMQDTISKFRDGHVTLLVATSVAEEGL
DIRQCNVVMRFDLAKTVLAYIQSRGRARKPGSDYILMVERGNVSHAAFLR
NARNSEETLRKEAIERTDLSHLKDTSRLISIDAVPGTVYKVEATGAMVSL
NSAVGLVHFYCSQLPGDRYAILRPEFSMEKHEKPGGHTEYSCRLQLPCNA
PFEILEGPVCSSMRLAQQAVCLAACKKLHEMGAEVCESSKLFHSEFAILF
GNELDAEVLSMSMDLYVARAMITKASLAFKGSLDITENQLSSLKKFHVRL
MSIVLDYLFVPVTGINWELVEKITKTLMMADGCMVAEDLIGKRFYVDSIC
YDMSAETSFPRKEGYLGPLEYNTYADYYKQKYGVDLNCKQQPLIKGRGVS
YVLDKTYYVFLPPELCVVHPLSGSLIRGAQRLPSIMRRVESMLLAVQLKN
LISYPIPTSKILEALTAASCQETFCYERAELLGDAYLKWVVSRFLFLKYP
QKHEGQLTRMRQQMVSNMVLYQFALVKGLQSYRVLSSKTLADVVEALIGV
YYVEGGKIAANHLMKWIGIDFVGLERALKYEFKEKGLLVEAITHASRPSS
GVSCYQRLEFVGDAVLDHLITRHLFFTYTSLPPGRLTDLRAAAVNNENFA
RVAVKHKLHLYLRHGSSALEKQIREFVKEVQKVLGDIVESIAGAIFLDSG
KDTTAAWKVFQPLLQPMVTPETLPMHPVRELQERCQQQAEGLEYKASRSG
NTATVEVFIDGVQVGVAQNPQKKMAQKLAARNALAAL
Ligand information
>7eld Chain B (length=109) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugagccaaaaguucaggugaaugaugccuggcucgagaccauucaaucuc
auguaugagaugugaugaugucggaccaggcuucauuccccucaacuuuu
gccucaauc
<<<<.<<<<<<<<.<<<.<<<<<<.<<<<<<.<<<<.<.<<<<..<<<<<
<<..>>>>>>>..>>>>.>.>>>>.>>>>>>.>>>>>>.>>>.>>>>>>>
>.>>>>...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7eld Structural basis of microRNA processing by Dicer-like 1.
Resolution4.6 Å
Binding residue
(original residue number in PDB)		P304 K305 E330 M331 G332 D334 W336 T354 Q356 I357 V384 K386 H387 K419 S423 H532 R535 R673 V674 S697 M698 I699 H701 V732 K752 S849 Y856 R901 R1242 K1243 Y1258 K1262 V1300 D1302 K1303 Y1306 V1307 D1626 M1732 H1733 R1736 Q1739 E1740 Q1743 Q1744 S1754 K1779 K1780
Binding residue
(residue number reindexed from 1)		P55 K56 E81 M82 G83 D85 W87 T105 Q107 I108 V135 K137 H138 K170 S174 H251 R254 R336 V337 S360 M361 I362 H364 V395 K415 S512 Y519 R564 R711 K712 Y727 K731 V752 D754 K755 Y758 V759 D988 M1075 H1076 R1079 Q1082 E1083 Q1086 Q1087 S1097 K1122 K1123
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0004519 endonuclease activity
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters
GO:0046872 metal ion binding
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0010267 ta-siRNA processing
GO:0030422 siRNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7eld, PDBe:7eld, PDBj:7eld
PDBsum7eld
PubMed34593993
UniProtQ9SP32|DCL1_ARATH Endoribonuclease Dicer homolog 1 (Gene Name=DCL1)

[Back to BioLiP]