Structure of PDB 7elc Chain A Binding Site BS01

Receptor Information
>7elc Chain A (length=1409) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DEYVQELKGLIRKHRCEFGHQKSPLLTEGFKLLSSLVELESCEAHACQAN
TDQRFVDVILSDNGILCPTLPKVIPDGFKLTGKTLILLETFVRVNPDEFE
KKWKADMSKLLNLKHDLQKSGVTLVPIVDGRSNYNNRFVADWVIERIRWL
LIEILKASEDQEYQRLIHSLSNVKLENLEHLKRNSLDYDERLNESLFIGL
KGDIRESTVREELIKLKLWFKDEVFSKGLGKFKLTDRRELLESLSSLGAH
LDSDVSSCPFCNNKLMEIVYNVTFSCVERTDTHSNIEKHYLSVLSLCNKI
KGLKVFNTRRNTLLFLDLIMVNLMVDISDSCQDAIESLRKSGLIVGQMVM
LVNDRVLDILEAVKLIRKKIGTNPNWVKNCSKILERSHPEIWHHLSTLIK
QPDFNSLISIAQHLVSDRPIMRYSVKICRHKLFQEMSSFEQMRLFKTLSS
ISLSLINSMKTSFSSRLLVNEKYFGNVRLRECYAQRFYLAESLVGFLFYQ
KTGERSRCYSVYLSDNGVMSEQGSFYCDPKRFFLPVFSDEVLAGMCEEMT
SWLDFDTGLMNDTGPILRLLVLAILCSPSKRNQTFLQGLRYFLMAFANQI
HHIDLTSKLVVECKSSSEVVVQRLAVGLFIRLLSGESDASLFFSRRFKYL
LNVSYLCHLITKETPDRLTDQIKCFEKFIEPKVKFGCAVVNPSLNGKLTV
DQEDIMINGLKKFFSKSLRDTEDVQTPGVCKELLNYCVSLFNRGKLKVSG
ELKNNPFRSPTEFTSISSNSGNLKFGLSYKEQVGSNRELYVGDLNTKLMT
RLVEDFSEAVGNSMKYTCLNSEKEFERAICDMKMAVNNGDLSCSYDHSKW
GPTMSPALFLALLQMLELRTPVDRSKIDLDSVKSILKWHLHKVVEVPINV
AEAYCIGSTSLSEEFFHQTMQLNGQIPSHIMSVLDMGQGILHNTSDLYGL
ITEQFLCYALDLLYDVIPVSYTSSDDQITLIKTPSDAAEWLEMICFHEFL
SSKLNKFVSPKSVIGTFVAEFKSRFFVMGEETPLLTKFVAAALHNVKCKT
PTQLSETIDTICDQCIANGVSTKIVTRISKRVNQLIRYSGYGETPFGAIE
DQDVKDWVDGSRGYRLQRKIEAIFHDDKETSFIRNCARKVFNDIKRGRIF
EENLINLIGRGGDEALTGFLQYAGCSEQEVNRVLNYRWVNLSSFGDLRLV
LRVPTLIKTLQSKLSRQSSVASGFIGFCKSMGSKCVRDGKGGFLYIKEVY
SGVSACTCEICALKPKIIYCNNSLNKVSQFSKPILWDYFSLVLTNACELG
EWVFSTVKEPQNNQNFFWAVKPKVVRQIEDGMNHVLQSIRRNYPVLFDEH
LTPFMNDLQVSRLKFLDVCIALDMMNENLGIISHLLKTRDNSVYIVKQSD
CALAHIRQS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7elc Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E324 S332 N335 K336 G339 K341 D391 L495 S496 K502 T503 S504 R532 F533 Y534 Y1449 K1623
Binding residue
(residue number reindexed from 1)		E287 S295 N298 K299 G302 K304 D354 L453 S454 K460 T461 S462 R486 F487 Y488 Y1088 K1229
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7elc, PDBe:7elc, PDBj:7elc
PDBsum7elc
PubMed34127846
UniProtQ6IVU0

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