Structure of PDB 7elb Chain A Binding Site BS01

Receptor Information
>7elb Chain A (length=1937) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DEYVQELKGLIRKHIPERCEFGHQKVTFLSQVHPSPLLTEGFKLLSSLVE
LESCEAHACQANTDQRFVDVILSDNGILCPTLPKVIPDGFKLTGKTLILL
ETFVRVNPDEFEKKWKADMSKLLNLKHDLQKSGVTLVPIVDGRSNYNNRF
VADWVIERIRWLLIEILKASKSEDQEYQRLIHSLSNVKLENLEHLKRNSL
DYDERLNESLFIGLKGDIRESTVREELIKLKLWFKDEVFSKGLGKFKLTD
RRELLESLSSLGAHLDSDVSSCPFCNNKLMEIVYNVTFSCVERSNIEKHY
LSVLSLCNKIKGLKVFNTRRNTLLFLDLIMVNLMVDISDSCQDAIESLRK
SGLIVGQMVMLVNDRVLDILEAVKLIRKKIGTNPNWVKNCSKILERSHPE
IWHHLSTLIKQPDFNSLISIAQHLVSDRPIMRYSKICRHKLFQEMSSFEQ
MRLFKTLSSISLSLINSMKTSFSSRLLVNEFGNVRLRECYAQRFYLAESL
VGFLFYQKTGERSRCYSVYLSDNGVMSEQGSFYCDPKRFFLPVFSDEVLA
GMCEEMTSWLDFDTGLMNDTGPILRLLVLAILCSPSKRNQTFLQGLRYFL
MAFANQIHHIDLTSKLVVECKSSSEVVVQRLAVGLFIRLLSGESDASLFF
SRRFKYLLNVSYLCHLITKETPDRLTDQIKCFEKFIEPKVKFGCAVVNPS
LNGKLTVDQEDIMINGLKKFFSKSLRDTEDVQTPGVCKELLNYCVSLFNR
GKLKVSGELKNNPFRIPKLDELGNILSTYDKEKLVSACVSSMAERFKNLD
PDSTDYLILKNLTTQEELSLMYEALTEEQVESFNEIKHDVQVALAKMADV
SLHEVKDFDPDVLPPEVYKELCDAVYKSSEKCNFFLEGVLDVCPLGLLLK
NLTTSSYVDEEYFMCFKYLLIQGHFDQFTNAALRNLCFYSEDSPTEFTSI
SSNSGNLKFGLSYKEQVGSNRELYVGDLNTKLMTRLVEDFSEAVGNSMKY
TCLNSEKEFERAICDMKMAVNNGDLSCSYDHSKWGPTMSPALFLALLQML
ELRTPVDRSKIDLDSVKSILKWHLHKVVEVPINVAEAYCIGSTSLSEEFF
HQTMQLNGQIPSHIMSVLDMGQGILHNTSDLYGLITEQFLCYALDLLYDV
IPVSYTSSDDQITLIKTPSDAAEWLEMICFHEFLSSKLNKFVSPKSVIGT
FVAEFKSRFFVMGEETPLLTKFVAAALHNVKCKTPTQLSETIDTICDQCI
ANGVSTKIVTRISKRVNQLIRYSGYGETPFGAIEDQDVKDWVDGSRGYRL
QRKIEAIFHDDKETSFIRNCARKVFNDIKRGRIFEENLINLIGRGGDEAL
TGFLQYAGCSEQEVNRVLNYRWVNLSSFGDLRLVLRTKLMTVPTLIKTLQ
SKLSRQSSVASGFIGFCKSMGSKCVRDGGFLYIKEVYSGVSACTCEICAL
KPKIIYCNNSLNKVSQFSKPILWDYFSLVLTNACELGEWVFSTVKEPQNN
QNFFWAVKPKVVRQIEDQLGMNHVLQSIRRNYPVLFDEHLTPFMNDLQVS
RTMDSGRLKFLDVCIALDMMNENLGIISHLLKTRDNSVYIVKQSDCALAH
IRQSSYTDWELGLSPQQICTNFKTQLVLSSMVNPLVLSTSCLKSFFWFNE
VLELEDDSQIELAELTDFALMVKNQNVSRAMFVEDIAMGYVVSNFEGVRI
SLSNVMVDGVQLPPQDIGELFGLKAGLVVQIDHVRMSTKFKLKRKMVYSF
SLECIMDVGEIQNKEVILKVVAVDQSVSGSGGNHMLLDGVSVVASLPLFT
GQASFDLAAMLIESNLAGSNDNFLMRNVTLDLGGFSPELSDKYSYRLSGP
ENQEDPLVLKDGAFYVGGERLSTYKVEFTGDLVVKALGALEDDESVVSML
HQLWPYLKATSQVILFQQEDFTIVHDLYKKQLTKSIE
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7elb Chain A Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7elb Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		D1188 D1330 E1381
Binding residue
(residue number reindexed from 1)		D1030 D1160 E1204
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7elb, PDBe:7elb, PDBj:7elb
PDBsum7elb
PubMed34127846
UniProtQ6IVU0

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