Structure of PDB 7ef8 Chain A Binding Site BS01

Receptor Information
>7ef8 Chain A (length=402) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVSPYHLFSDVADVTAFRSNLLSWYDQEKRDLPWRNLAKEEANSDRRAYA
VWVSEVMLQQTQVATVIDYYTRWMQKWPKLQDLASASLEEVNQLWSGLGY
YSRGRRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFD
QVTGVVDGNVLRVLCRVRAIGADPTSTLVSHHLWNLAQQLVDPARPGDFN
QAAMELGATVCTPQRPLCSHCPVQSLCRAYQRVQEECACQLCLTSSSPWD
PSMGVANFPRKASRRPPREEYSATCVVEQPGAIGGPLVLLVQRPDSGLLA
GLWEFPSVTLEPSEQHQHKALLQELQRWCGPLPAIRLQHLGEVIHIFSHI
KLTYQVYSLALDQAPASTAPPGARWLTWEEFCNAAVSTAMKKVFRMYEDH
RQ
Ligand information
Receptor-Ligand Complex Structure
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PDB7ef8 Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		Q110 T111 Q112 G147 G149 Y150 Y151 G365 L366 L367 H413 F415 S416 H417 S455 T456
Binding residue
(residue number reindexed from 1)		Q60 T61 Q62 G97 G99 Y100 Y101 G297 L298 L299 H345 F347 S348 H349 S387 T388
Enzymatic activity
Catalytic site (original residue number in PDB) E105 Y189 D207
Catalytic site (residue number reindexed from 1) E55 Y139 D157
Enzyme Commision number 3.2.2.31: adenine glycosylase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0019104 DNA N-glycosylase activity
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7ef8, PDBe:7ef8, PDBj:7ef8
PDBsum7ef8
PubMed34142156
UniProtQ99P21|MUTYH_MOUSE Adenine DNA glycosylase (Gene Name=Mutyh)

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