Structure of PDB 7e9l Chain A Binding Site BS01

Receptor Information

>7e9l Chain A (length=524) Species: 9913 (Bos taurus)

RIDYPKALQILTEGGTHMVCTGRTHTDRLCRFKWLCYSSEAEEFIFFHGN
ASVMLPSLGSRRFQPALLDLSTVEDHNTQYFNFVELPAAALRFMPKPVFV
PDVALIANRFNPDNLMHVFHDDLLPLFYTLRQFPGLAREARLFFMEGWGE
GAHFDLYKLLSPKQPLLRAQLKALGRLLCFSHAFVGLSKVTTWYQYGFVQ
PQGPKANILVSGNEIRQFAHFLMEKLNVSEEYILVFSRTQNRLILNEAEL
LLALAQEFQMKTVTVSLEDHAFADVVRLVSNASMLVSMHGAQLVTALFLP
RGAAVVELFPYAVNPDHYTPYKTLATLPGMDLQYIAWQNTMPENTVTHPE
RPWDQGGIAHLDRAEQARILQSREVPRHLCCRNPEWLFRIYQDTKVDIPS
LIQTIRRVVKGHPGPRKQKWTVSLYPGKVREARCQASVQGASEARLSVSW
QIPWNLKYLKVREVKYEVWLQEQGENTYVPYMLALQNHTFTENIKPFTTY
LVWIRCIFNKTLLGPFADVLVCST

Ligand information

>7e9l Chain C (length=12) Species: 9606 (Homo sapiens)

QTPTLGPIQPTR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7e9l The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on alpha-dystroglycan.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): H125 N126 F159 N160 F247 R438
• Binding residue (residue number reindexed from 1): H76 N77 F110 N111 F198 R382

Enzymatic activity

• Enzyme Commision number: 2.4.1.312: protein O-mannose beta-1,4-N-acetylglucosaminyltransferase.

Gene Ontology

Molecular Function

• GO:0008375 acetylglucosaminyltransferase activity
• GO:0016757 glycosyltransferase activity
• GO:0097363 protein O-acetylglucosaminyltransferase activity

Biological Process

• GO:0001764 neuron migration
• GO:0006486 protein glycosylation
• GO:0006493 protein O-linked glycosylation
• GO:0035269 protein O-linked mannosylation

Cellular Component

• GO:0005783 endoplasmic reticulum
• GO:0005789 endoplasmic reticulum membrane
• GO:0016020 membrane

External links

• PDB: RCSB:7e9l, PDBe:7e9l, PDBj:7e9l
• PDBsum: 7e9l
• PubMed: 33893702
• UniProt: Q5NDF2|PMGT2_BOVIN Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (Gene Name=POMGNT2)