Structure of PDB 7e37 Chain A Binding Site BS01

Receptor Information

>7e37 Chain A (length=305) Species: 93608 (Sinopodophyllum hexandrum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PLRLPVIDLSMKNLKPGTTSWNSVRTQVREALEEYGCFEAVIDAVSPELQ
KAVCNKGHELLNLPLETKMLNGNKPEYDGFTSIPNLNEGMGVGRITDLEK
VERFTNLMWPEGNKDFCETVYSYGKRMAEVDHILKMMVFESFGMEKHFDS
FCESTNYLLHFMRYQQPGKDGRSPALSLHKDKSILTIVNQNDVKGLEFET
KDGEWILPTADNHIVLLGDCFMAWSNGRLHSPLHRVTLVANQARLSTSSF
SFPKDIIETPAELVDEEHPLLFNPFEITELLAYCFTDLKQYKAYTGALEH
HHHHH

Ligand information

Ligand ID

InChI

InChI=1S/Fe/q+3

InChIKey

VTLYFUHAOXGGBS-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Fe+3]

Formula

Name

FE (III) ION

PDB chain

7e37 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7e37 Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase.
Resolution	2.09 Å
Binding residue (original residue number in PDB)	H184 D186 H239
Binding residue (residue number reindexed from 1)	H179 D181 H234
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.20.8: (-)-deoxypodophyllotoxin synthase.

Gene Ontology

	Molecular Function
GO:0016706	2-oxoglutarate-dependent dioxygenase activity
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

	Biological Process
GO:0009611	response to wounding
GO:0009699	phenylpropanoid biosynthetic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:7e37, PDBe:7e37, PDBj:7e37
PDBsum	7e37
PubMed	34969844
UniProt	A0A0N9HQ36\|2ODD_SINHE Deoxypodophyllotoxin synthase (Gene Name=2-ODD)

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