Structure of PDB 7e25 Chain A Binding Site BS01

Receptor Information
>7e25 Chain A (length=139) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPRGSHMMVEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVII
SQEGDKVVIRTLSTFKNTEISFQLGEEFDETTADDRNCKSVVSLDGDKLV
HIQKWDGKETNFVREIKDGKMVMTLTFGDVVAVRHYEKA
Ligand information
Ligand IDPLM
InChIInChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)
InChIKeyIPCSVZSSVZVIGE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CCCCCCCCCCCCCCCC(=O)O
ACDLabs 10.04O=C(O)CCCCCCCCCCCCCCC
CACTVS 3.341CCCCCCCCCCCCCCCC(O)=O
FormulaC16 H32 O2
NamePALMITIC ACID
ChEMBLCHEMBL82293
DrugBankDB03796
ZINCZINC000006072466
PDB chain7e25 Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7e25 Crystal structure of human brain-type fatty acid-binding protein FABP7 complexed with palmitic acid.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		S56 D77 R127 Y129
Binding residue
(residue number reindexed from 1)		S63 D84 R134 Y136
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0007399 nervous system development
GO:0008285 negative regulation of cell population proliferation
GO:0015908 fatty acid transport
GO:0050673 epithelial cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7e25, PDBe:7e25, PDBj:7e25
PDBsum7e25
PubMed34196621
UniProtO15540|FABP7_HUMAN Fatty acid-binding protein, brain (Gene Name=FABP7)

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