Structure of PDB 7e1t Chain A Binding Site BS01

Receptor Information
>7e1t Chain A (length=170) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLFKVILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVDGHF
VTMQIWDTAGLERFRSLRTPFYRGSDCCLLTFSVDDSQSFQNLSNWKKEF
IYYADVKEPESFPFVILGNKIDISERQVSTEEAQAWCRDNGDYPYFETSA
KDATNVAAAFEEAVRRVLAT
Ligand information
>7e1t Chain D (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MDDLAQTKAIKDQLQKYIRELEQAN
Receptor-Ligand Complex Structure
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PDB7e1t Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		V42 F44 W61 R68 F69 L72 F76
Binding residue
(residue number reindexed from 1)		V37 F39 W56 R63 F64 L67 F71
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
Biological Process
GO:0015031 protein transport
GO:0032482 Rab protein signal transduction
GO:0032880 regulation of protein localization
GO:0042147 retrograde transport, endosome to Golgi
GO:0045921 positive regulation of exocytosis
GO:0052403 negative regulation by host of symbiont catalytic activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005764 lysosome
GO:0005768 endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030133 transport vesicle
GO:0030670 phagocytic vesicle membrane
GO:0032588 trans-Golgi network membrane
GO:0042470 melanosome
GO:0045335 phagocytic vesicle
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7e1t, PDBe:7e1t, PDBj:7e1t
PDBsum7e1t
PubMed34793709
UniProtP51151|RAB9A_HUMAN Ras-related protein Rab-9A (Gene Name=RAB9A)

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