Structure of PDB 7dvx Chain A Binding Site BS01

Receptor Information

>7dvx Chain A (length=306) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2)

SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRAVICTSEDML
NPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPK
YKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGF
NIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTI
TVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL
GPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQC
SGVTFQ

Ligand information

>7dvx Chain C (length=10) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2)

KVATVQSKMS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7dvx Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): T24 T25 T26 T45 S46 M49 F140 G143 S144 C145 H163 H164 M165 E166 P168 Q189 T190
• Binding residue (residue number reindexed from 1): T24 T25 T26 T45 S46 M49 F140 G143 S144 C145 H163 H164 M165 E166 P168 Q189 T190

Enzymatic activity

• Enzyme Commision number: 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  2.7.7.50: mRNA guanylyltransferase.
  3.1.13.-
  3.4.19.12: ubiquitinyl hydrolase 1.
  3.4.22.-
  3.4.22.69: SARS coronavirus main proteinase.
  3.6.4.12: DNA helicase.
  3.6.4.13: RNA helicase.
  4.6.1.-

Gene Ontology

Molecular Function

• GO:0008233 peptidase activity

Biological Process

• GO:0019082 viral protein processing

External links

• PDB: RCSB:7dvx, PDBe:7dvx, PDBj:7dvx
• PDBsum: 7dvx
• PubMed: 35380892
• UniProt: P0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)