Structure of PDB 7du4 Chain A Binding Site BS01

Receptor Information
>7du4 Chain A (length=106) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEPRRGDLWLVSLGGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTP
LRPPVAPSEGVAADSVAVCRGVRAVARARLVERLGALKPATMRAIENALT
LILGLP
Ligand information
>7du4 Chain Q (length=10) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EWEGTVGDGL
Receptor-Ligand Complex Structure
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PDB7du4 Mechanistic Insight into the Peptide Binding Modes to Two M. tb MazF Toxins.
Resolution2.18 Å
Binding residue
(original residue number in PDB)		V12 L14 P49 R81 V83 A84 R87
Binding residue
(residue number reindexed from 1)		V11 L13 P41 R73 V75 A76 R79
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
Biological Process
GO:0006402 mRNA catabolic process
GO:0016075 rRNA catabolic process
GO:0017148 negative regulation of translation
GO:0044003 symbiont-mediated perturbation of host process
GO:0045926 negative regulation of growth

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Molecular Function
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Biological Process
External links
PDB RCSB:7du4, PDBe:7du4, PDBj:7du4
PDBsum7du4
PubMed33925254
UniProtP0CL62|MAZF7_MYCTU Probable endoribonuclease MazF7 (Gene Name=mazF7)

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