Structure of PDB 7drk Chain A Binding Site BS01

Receptor Information

>7drk Chain A (length=184) Species: 158879 (Staphylococcus aureus subsp. aureus N315)

NIPNQITVFRVVLIPVFILFALVDFGFGNVSFLGGYEIRIELLISGFIFI
LASLSDFVDGYLARKWNLVTNMGKFLDPLADKLLVASALIVLVQLGLTNS
VVAIIIIAREFAVTGLRLLQIEQGFVSAAGQLGKIKTAVTMVAITWLLLG
DPLATLIGLSLGQILLYIGVIFTILSGIEYFYKG

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7drk Chain A Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7drk The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): D57 D60 D78
• Binding residue (residue number reindexed from 1): D56 D59 D77
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.8.5: CDP-diacylglycerol--glycerol-3-phosphate 1-phosphatidyltransferase.

Gene Ontology

Molecular Function

• GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
• GO:0016740 transferase activity
• GO:0016780 phosphotransferase activity, for other substituted phosphate groups

Biological Process

• GO:0006655 phosphatidylglycerol biosynthetic process
• GO:0008654 phospholipid biosynthetic process
• GO:0046474 glycerophospholipid biosynthetic process

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:7drk, PDBe:7drk, PDBj:7drk
• PDBsum: 7drk
• PubMed: 34901881
• UniProt: P63756|PGSA_STAAN CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (Gene Name=pgsA)