Structure of PDB 7dp3 Chain A Binding Site BS01

Receptor Information
>7dp3 Chain A (length=278) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PYKGWKLYFSEVYSDSSPLIEKIQAFEKFFTRHIDLYDKDEIERKGSILV
DFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTKDLERHAA
ELQAQTMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNI
KPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSP
LTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTI
TGIVKVSNANDKCMFLLYIEANSISNSK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7dp3 Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7dp3 Structural study of the N-terminal domain of human MCM8/9 complex.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		C242 C264
Binding residue
(residue number reindexed from 1)		C161 C183
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
Biological Process
GO:0032508 DNA duplex unwinding

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Molecular Function
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Biological Process
External links
PDB RCSB:7dp3, PDBe:7dp3, PDBj:7dp3
PDBsum7dp3
PubMed34043945
UniProtQ9UJA3|MCM8_HUMAN DNA helicase MCM8 (Gene Name=MCM8)

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