Structure of PDB 7dol Chain A Binding Site BS01

Receptor Information
>7dol Chain A (length=565) Species: 243273 (Mycoplasmoides genitalium G37) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ILTLHYSTGALDGDDAAVITILKRARILYAGNFLVLEYKIVADNPRFYLT
MIVNPDSIPNNLASNTKIAFQIDEYDPDNNLCKVSVQQVLGNNDDPLINI
KAIMLDNSIVFETNDVVEQHANKLSFDTEEQHKAYRQDLTDLAFVTVDPT
TSKDLADAIYVKTIPTGFVLYVAIADVAHYVNRNSEIDIEAKHKTSSIYL
PGHYVVPMLPEQLSNQLCSLNPAQKRYVVVCEISFDNQGRIKTNKLYPAT
IISKNRFSYDQVNKWLNNKSELNCDETVINSLKAAFTLSDLIQAQRQKRG
TIDLSHKETEIVVDEHYFPIKINFLVHDKAETMIENLMVVANETVAWVLT
NNKIALPYRVHPRPSKKKLQSLIETVGELNITKPQFNLDTVTSSQIASWL
NENKDNPSYEIFVILLLRTLGKAFYSVNPLMHFSIGSNHYTHFTSPIRRY
IDLTIHRLLWMHLFTPDQFTDNERDQLKQELEKIADTVNDTEIKIINCER
NANDYLTTLLLSKQIGKTFSGFISAFGIFMRMDENNFDGLIIGDRLEAKL
SEIDFIQKRAILTLI
Ligand information
Receptor-Ligand Complex Structure
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PDB7dol Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation.
Resolution2.002 Å
Binding residue
(original residue number in PDB)		D276 S280 D282 D285 Y327 Y387 L432 H434 E436 E463 M466 R487 H489 L545 G549 K550 A551 H560 S562 I563 Y568 H570 T572 R576
Binding residue
(residue number reindexed from 1)		D148 S152 D154 D157 Y199 Y259 L304 H306 E308 E335 M338 R359 H361 L417 G421 K422 A423 H432 S434 I435 Y440 H442 T444 R448
Enzymatic activity
Catalytic site (original residue number in PDB) D276 D282 A284 D285 Y387 R576
Catalytic site (residue number reindexed from 1) D148 D154 A156 D157 Y259 R448
Enzyme Commision number 3.1.13.1: exoribonuclease II.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0004540 RNA nuclease activity
GO:0008859 exoribonuclease II activity
Biological Process
GO:0006402 mRNA catabolic process
GO:0016070 RNA metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dol, PDBe:7dol, PDBj:7dol
PDBsum7dol
PubMed33788943
UniProtP47350|RNR_MYCGE Ribonuclease R (Gene Name=rnr)

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