Structure of PDB 7did Chain A Binding Site BS01

Receptor Information
>7did Chain A (length=644) Species: 243273 (Mycoplasmoides genitalium G37) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQGILTLGNKNSGFIRSLDDDKTVYYVHYSNLTGALDGDLVEFCKLDKPQ
FGDKFDAAVITILKRARILYAGNFLVDQNEFALEYKIVADNPRFYLTMIV
NPDSIPNNLASNTKIAFQIDEYDPDNNLCKVSVQQVLGNNDDPLINIKAI
MLDNSIVFETNDVVEQHANKLSFDTEEQHKAYRQDLTDLAFVTVDPTTSK
DLADAIYVKTIPTGFVLYVAIADVAHYVNRNSEIDIEAKHKTSSIYLPGH
YVVPMLPEQLSNQLCSLNPAQKRYVVVCEISFDNQGRIKTNKLYPATIIS
KNRFSYDQVNKWLNNKSELNCDETVINSLKAAFTLSDLIQAQRQKRGTID
LSHKETEIVVDEHYFPIKINFLVHDKAETMIENLMVVANETVAWVLTNNK
IALPYRVHPRPSKKKLQSLIETVGELNITKPQFNLDTVTSSQIASWLNEN
KDNPSYEIFVILLLRTLGKAFYSVNPLMHFSIGSNHYTHFTSPIRRYIDL
TIHRLLWMHLFTPDQFTDNERDQLKQELEKIADTVNDTEIKIINCERNAN
DYLTTLLLSKQIGKTFSGFISAITSFGIFMRMDENNFDGLIKITTIPDDF
FIFEKEKMVLKGRKTNKVYKIGDRLEAKLSEIDFIQKRAILTLI
Ligand information
Receptor-Ligand Complex Structure
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PDB7did Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		D285 L432 E459 E463 M466 R487 H489 L545 A551 H560 S562 I563 Y568 H570 T572 R576
Binding residue
(residue number reindexed from 1)		D204 L351 E378 E382 M385 R406 H408 L464 A470 H479 S481 I482 Y487 H489 T491 R495
Enzymatic activity
Catalytic site (original residue number in PDB) D276 D282 A284 D285 Y387 R576
Catalytic site (residue number reindexed from 1) D195 D201 A203 D204 Y306 R495
Enzyme Commision number 3.1.13.1: exoribonuclease II.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0004540 RNA nuclease activity
GO:0008859 exoribonuclease II activity
Biological Process
GO:0006402 mRNA catabolic process
GO:0016070 RNA metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7did, PDBe:7did, PDBj:7did
PDBsum7did
PubMed33788943
UniProtP47350|RNR_MYCGE Ribonuclease R (Gene Name=rnr)

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