Structure of PDB 7dh8 Chain A Binding Site BS01

Receptor Information

>7dh8 Chain A (length=141) Species: 314565 (Xanthomonas campestris pv. campestris str. 8004)

ANSFVRAVERACSERGLRLTPIRANVLRLIADAGKPVKAYELLDWVREAD
APPTVYRALDFLMANGFVHKLESVNAFVACHHPNSAQHSVPFLICDRCHS
AVELEDRDVVSQLEARAKALGFQPQAQTLEVHGLCAKCAAA

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7dh8 Chain A Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7dh8 Structural basis for zinc-induced activation of a zinc uptake transcriptional regulator.
• Resolution: 1.85 Å
• Binding residue (original residue number in PDB): H98 C109 H117 E132
• Binding residue (residue number reindexed from 1): H69 C80 H88 E103
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0000976 transcription cis-regulatory region binding
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0045892 negative regulation of DNA-templated transcription
• GO:1900376 regulation of secondary metabolite biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:7dh8, PDBe:7dh8, PDBj:7dh8
• PDBsum: 7dh8
• PubMed: 34048589
• UniProt: Q4UWS5