Structure of PDB 7dge Chain A Binding Site BS01

Receptor Information
>7dge Chain A (length=784) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFH
TLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLIGRTKKP
IAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVV
PSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCI
AHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRR
LGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFL
KLRLDTNHRNPWFQEFWQHRFQCRLEGFPQENSNFKRICTGNESLEENYV
QDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLI
KSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVL
NIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEY
VQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGIL
VTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTT
SCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWA
QVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVA
PLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIY
FGSNYKIITTCFAVSLSVTVALGCMFTPKMYIII
Ligand information
Ligand IDQUS
InChIInChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
InChIKeyASNFTDCKZKHJSW-REOHCLBHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CN1OC(=O)NC1=O)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)N1C(=O)NC(=O)O1
ACDLabs 10.04O=C1NC(=O)ON1CC(N)C(=O)O
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)N1C(=O)NC(=O)O1
CACTVS 3.341N[C@@H](CN1OC(=O)NC1=O)C(O)=O
FormulaC5 H7 N3 O5
Name(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID;
QUISQUALATE
ChEMBLCHEMBL279956
DrugBankDB02999
ZINCZINC000000897456
PDB chain7dge Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7dge Structural insights into the activation initiation of full-length mGlu1.
Resolution3.65 Å
Binding residue
(original residue number in PDB)		Y74 W110 G163 S164 S165 S186 T188 Y236 E292 G319 R323
Binding residue
(residue number reindexed from 1)		Y40 W76 G108 S109 S110 S131 T133 Y181 E237 G264 R268
Annotation score1
Binding affinityBindingDB: Ki=10nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dge, PDBe:7dge, PDBj:7dge
PDBsum7dge
PubMed33278019
UniProtQ13255|GRM1_HUMAN Metabotropic glutamate receptor 1 (Gene Name=GRM1)

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