Structure of PDB 7dg2 Chain A Binding Site BS01

Receptor Information
>7dg2 Chain A (length=231) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDRINESHQRFLQALMSHGIMEGSAVRALHRHCCELHKVHYMHDKLDDFV
GVLNRHLQPLFMTIEKGVGEEDGLTYYALVNRVENDITKMASDYAENELE
LFRKTMELIILSDNGFATSISILNLADELQSKKMKKKEVEQLLQSFVQEK
WLIGRNGEYTLHTRCIMELEHYIRNTYQDVAKICNVCRKVAIQSQLCENC
GIPLHLQCAGKYFHKANPTCPNCNESWPHEI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7dg2 Chain A Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7dg2 Structure Basis for Shaping the Nse4 Protein by the Nse1 and Nse3 Dimer within the Smc5/6 Complex.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		C185 C188 H206 C209
Binding residue
(residue number reindexed from 1)		C184 C187 H205 C208
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006974 DNA damage response
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005694 chromosome
GO:0030915 Smc5-Smc6 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dg2, PDBe:7dg2, PDBj:7dg2
PDBsum7dg2
PubMed33676928
UniProtQ6PAF4|NSE1_XENLA Non-structural maintenance of chromosomes element 1 homolog (Gene Name=nsmce1)

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