Structure of PDB 7das Chain A Binding Site BS01

Receptor Information

>7das Chain A (length=674) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NLYFQSQCTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTN
FTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFV
FCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQL
ENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTI
GKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSG
LKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYG
LSNLRYLSLKRAFTKQSASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSN
TFTGLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIA
NGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLST
SSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINE
DLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNG
LDEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLIT
SVEKDVFGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELST
HYLCNTPHHYYGFPLKLFDTSSCK

Ligand information

>7das Chain C (length=66) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ugaaggccuguuuccuaggcuacauacgagggaccgcaccaaccacacgg
ggcucauucucagcgc

<...<<..<<..<<<..<......<...............>......>.>
>>..>>..>>....>.

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7das Endosomal lncRNA Rmrp is required for TLR3 innate sensing by engaging TLR3 dimerization
Resolution	3.64 Å
Binding residue (original residue number in PDB)	K42 H61 N62 F85 N86 H109 E111 R490 N516 N518 H540 N542 S572
Binding residue (residue number reindexed from 1)	K21 H40 N41 F64 N65 H88 E90 R466 N492 N494 H516 N518 S548

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:7das, PDBe:7das, PDBj:7das
PDBsum	7das
PubMed
UniProt	Q99MB1\|TLR3_MOUSE Toll-like receptor 3 (Gene Name=Tlr3)

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