Structure of PDB 7d99 Chain A Binding Site BS01

Receptor Information
>7d99 Chain A (length=891) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSSLLNKLANYTNLSQGVVEHEEDPRMGTFIGVYLPCLQNILGVILFLRL
TWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISR
SLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAAG
GEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAI
YAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGL
FCNGSQPSAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVE
KKGVPSVPVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRS
GDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQ
GNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPF
LQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLF
VNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSA
MLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWR
PQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHME
AQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTV
LMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERF
GGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQM
KKDLQMFLYHLRISAEVEVVEMQSNVRRMHTAVKLNGVVLNKSQDAQLVL
LNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVI
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain7d99 Chain A Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7d99 Structures and an activation mechanism of human potassium-chloride cotransporters.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		N131 I132 P429 S430 T432
Binding residue
(residue number reindexed from 1)		N40 I41 P338 S339 T341
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015293 symporter activity
GO:0015377 chloride:monoatomic cation symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0019901 protein kinase binding
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0006884 cell volume homeostasis
GO:0007268 chemical synaptic transmission
GO:0055064 chloride ion homeostasis
GO:0055075 potassium ion homeostasis
GO:0055085 transmembrane transport
GO:0071333 cellular response to glucose stimulus
GO:0071805 potassium ion transmembrane transport
GO:1902476 chloride transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0045202 synapse

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7d99, PDBe:7d99, PDBj:7d99
PDBsum7d99
PubMed33310850
UniProtQ9Y666|S12A7_HUMAN Solute carrier family 12 member 7 (Gene Name=SLC12A7)

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