Structure of PDB 7d7p Chain A Binding Site BS01

Receptor Information
>7d7p Chain A (length=329) Species: 946362 (Salpingoeca rosetta) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGHSAAMDAEKLAASSLFTWDFDALDKSDEDLTAVCVRVFQELHVIEQFN
IDEKKLRKWLQKVRTQYNKNPFHNWRHAVMVLHTTYLLLTSVATEFITEV
ELLAMLIAALSHDLDHNGLTNAFHINSRSELALVYNDQSVLENHHSHLAF
EILLEKGCNVVENLDEDEFKRLRAVIINCILNTDMATHHTKLSKMEEVNR
LGGFINLAENNDQRLFVLAVLLHTADLHNPIKPFESNKRWSARLQKEFNN
QVELEAKMNLPSLPFMRGNDEESLAKGEIGFINFVVKPWHQQLSQAFPKL
DFLLDTIDANLAEWKAIAESYRQMQENLY
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7d7p Chain A Residue 806 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7d7p Structural insights into the mechanism of rhodopsin phosphodiesterase.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		H456 H491 D492 D605
Binding residue
(residue number reindexed from 1)		H77 H112 D113 D226
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:7d7p, PDBe:7d7p, PDBj:7d7p
PDBsum7d7p
PubMed33154353
UniProtF2TZN0

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