Structure of PDB 7d58 Chain A Binding Site BS01

Receptor Information
>7d58 Chain A (length=1387) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPL
LYGVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAV
IGILQMICKTCCHIMLSQEEKKQFLDYLKRPGLTYLQKRGLKKKISDKCR
KKNICHHCGAFNGTVKKCGLLKIIHEKYKTNKKVVDPIVSNFLQSFETAI
EHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLMNPEAGKPSDLI
LTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISGA
KTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGR
FRGNLSGKRVDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANI
NFLRKLVQNGPEVHPGANFIQQRHTQMKRFLKYGNREKMAQELKYGDIVE
RHLIDGDVVLFNRQPSLHKLSIMAHLARVKPHRTFRFNECVCTPYNADFD
GDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYL
LTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQIF
SVILRPSDDNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMD
KGTLGSGSKNNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIG
DVTPGQGLLKAKYELLNAGYKKCDEYIEALNTGKLQQQPGCTAEETLEAL
ILKELSVIRDHAGSACLRELDKSNSPLTMALCGSKGSFINISQMIACVGQ
QAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHT
MAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFI
YGGDGLDPAAMEGKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTES
IMKKSEFLCCQDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLY
QLDRITPTQVEKFLETCRDKYMRAQMEPGSAVGALCAQSIGEPGTQMTLK
TFHFAGVASMNITLGVPRIKEIINASKAISTPIITAQLDKDDDADYARLV
KGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLLRLEVNAETVRY
SICTSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVVV
QGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNT
YEVEKTLGIEAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVL
GITRFGLAKMKESVLMLASFEKTADHLFDAAYFGQKDSVCGVSECIIMGI
PMNIGTGLFKLLHKADRDPNPPKRPLIFDTNEFHIPL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7d58 Structural insights into transcriptional regulation of human RNA polymerase III.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		S326 K346 K348 R360 R366 Q465 T865 A866 Y870 R1305 E1322 K1323
Binding residue
(residue number reindexed from 1)		S325 K345 K347 R359 R365 Q464 T864 A865 Y869 R1304 E1321 K1322
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0032728 positive regulation of interferon-beta production
GO:0042797 tRNA transcription by RNA polymerase III
GO:0045087 innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7d58, PDBe:7d58, PDBj:7d58
PDBsum7d58
PubMed33558766
UniProtO14802|RPC1_HUMAN DNA-directed RNA polymerase III subunit RPC1 (Gene Name=POLR3A)

[Back to BioLiP]