Structure of PDB 7d3c Chain A Binding Site BS01

Receptor Information

>7d3c Chain A (length=303) Species: 1335626 (Middle East respiratory syndrome-related coronavirus)

SGLVKMSHPSGDVEACMVQVTCGSMTLNGLWLDDTVWCPRHVMCPADQLS
DPNYDALLISMTNHSFSVQKHIGAPANLRVVGHAMQGTLLKLTVDVANPS
TPAYTFTTVKPGAAFSVLACYNGRPTGTFTVVMRPNYTIKGSFLCGSCGS
VGYTKEGSVINFCYMHQMELANGTHTGSAFDGTMYGAFMDKQVHQVQLTD
KYCSVNVVAWLYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVGTQS
VDMLAVKTGVAIEQLLYAIQQLYTGFQGKQILGSTMLEDEFTPEDVNMQI
MGV

Ligand information

>7d3c Chain C (length=5) Species: 32630 (synthetic construct)

gAVLa

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7d3c The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): H41 F143 G146 C148 H166 M168 E169 D190 Q192 V193 H194
• Binding residue (residue number reindexed from 1): H41 F143 G146 C148 H166 M168 E169 D190 Q192 V193 H194

Enzymatic activity

• Enzyme Commision number: 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  2.7.7.50: mRNA guanylyltransferase.
  3.1.13.-
  3.4.19.12: ubiquitinyl hydrolase 1.
  3.4.22.-
  3.6.4.12: DNA helicase.
  3.6.4.13: RNA helicase.
  4.6.1.-

Gene Ontology

Molecular Function

• GO:0008233 peptidase activity

Biological Process

• GO:0019082 viral protein processing

External links

• PDB: RCSB:7d3c, PDBe:7d3c, PDBj:7d3c
• PDBsum: 7d3c
• PubMed: 23549610
• UniProt: K9N7C7|R1AB_MERS1 Replicase polyprotein 1ab (Gene Name=rep)