Structure of PDB 7d1h Chain A Binding Site BS01

Receptor Information
>7d1h Chain A (length=326) Species: 6945 (Ixodes scapularis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKWPRDLRPLAHHDLLYMGQISEEDRGDFNATLRNFLVPRVVGSQKHREV
REFIVRSLKDLDWDVEEDCFDGQTPHGIKPFCNVIATLNPSACHRLVLAC
HYDSLLHKEGTFIGATDSAVPCAQLLYLARSLNGKLQNQKTRGDGLTLQL
VFFDGEEAFERWSSHDSLYGSRHLAQKWHEDRTSAERLESCLERSEIANQ
IDRMEVMVLLDLLGAENPRFYSYFGETQPVYRRLVNIESRLNDAGLMELP
RRRRRTNYFSNSSTVGFIEDDHIPFLKRSVPIVHIIPSPFPDVWHTLDDN
EQNLHHPTISNLNKIFKAFVSEYLQL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7d1h Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7d1h A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes.
Resolution1.69 Å
Binding residue
(original residue number in PDB)		D144 E184 H322
Binding residue
(residue number reindexed from 1)		D117 E157 H295
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.2.5: glutaminyl-peptide cyclotransferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016603 glutaminyl-peptide cyclotransferase activity
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7d1h, PDBe:7d1h, PDBj:7d1h
PDBsum7d1h
PubMed33774034
UniProtB7QK46|QPCT_IXOSC Glutaminyl-peptide cyclotransferase (Gene Name=Qptc)

[Back to BioLiP]