Structure of PDB 7d0s Chain A Binding Site BS01

Receptor Information
>7d0s Chain A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHM
AKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLY
YDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQG
YGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQ
GKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWI
AKEAKRSNSNKTMDPSCLKWTPPK
Ligand information
>7d0s Chain B (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GMVEIEIEGRLHRISIFDPLEIILEDDL
Receptor-Ligand Complex Structure
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PDB7d0s HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		K537 E538 I539 S540 I541 K542 Q560 Y567 W568 H572 V574 L575 K576
Binding residue
(residue number reindexed from 1)		K202 E203 I204 S205 I206 K207 Q225 Y232 W233 H237 V239 L240 K241
Enzymatic activity
Catalytic site (original residue number in PDB) C474 E508
Catalytic site (residue number reindexed from 1) C139 E173
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7d0s, PDBe:7d0s, PDBj:7d0s
PDBsum7d0s
PubMed34259319
UniProtO95251|KAT7_HUMAN Histone acetyltransferase KAT7 (Gene Name=KAT7)

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