Structure of PDB 7d0p Chain A Binding Site BS01

Receptor Information
>7d0p Chain A (length=276) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHM
AKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLY
YDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQG
YGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQ
GKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWI
AKEAKRSNSNKTMDPSCLKWTPPKGT
Ligand information
>7d0p Chain B (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GMVEIEIEGRLHRISIFDPLEIILEDDL
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7d0p HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		F534 K537 E538 I539 S540 I541 K542 P552 Y567 H572 L573 V574 L575 K576
Binding residue
(residue number reindexed from 1)		F199 K202 E203 I204 S205 I206 K207 P217 Y232 H237 L238 V239 L240 K241
Enzymatic activity
Catalytic site (original residue number in PDB) C474 E508
Catalytic site (residue number reindexed from 1) C139 E173
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7d0p, PDBe:7d0p, PDBj:7d0p
PDBsum7d0p
PubMed34259319
UniProtO95251|KAT7_HUMAN Histone acetyltransferase KAT7 (Gene Name=KAT7)

[Back to BioLiP]