Structure of PDB 7d0o Chain A Binding Site BS01

Receptor Information
>7d0o Chain A (length=273) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHM
AKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLY
YDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQG
YGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQ
GKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWI
AKEAKRSNSNKTMDPSCLKWTPP
Ligand information
>7d0o Chain B (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GMVEIEIEGRLHRISIFDPLEIILEDDL
Receptor-Ligand Complex Structure
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PDB7d0o HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.
Resolution2.51 Å
Binding residue
(original residue number in PDB)		F534 E538 I539 S540 K542 Q560 Y567 H572 L573 V574 L575 K576
Binding residue
(residue number reindexed from 1)		F199 E203 I204 S205 K207 Q225 Y232 H237 L238 V239 L240 K241
Enzymatic activity
Catalytic site (original residue number in PDB) C474 E508
Catalytic site (residue number reindexed from 1) C139 E173
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7d0o, PDBe:7d0o, PDBj:7d0o
PDBsum7d0o
PubMed34259319
UniProtO95251|KAT7_HUMAN Histone acetyltransferase KAT7 (Gene Name=KAT7)

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