Structure of PDB 7cwz Chain A Binding Site BS01

Receptor Information
>7cwz Chain A (length=601) Species: 1351 (Enterococcus faecalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGEMNLNALFIGDKAENGQLYKDLLIDLVDEHLGWRQNYMPQDMPVISSQ
ERTSKSYEKTVNHMKDVLNEISSRMRTHSVPWHTAGRYWGHMNSETLMPS
LLAYNFAMLWNGNNVAYESSPATSQMEEEVGHEFAHLMSYKNGWGHIVAD
GSLANLEGLWYARNIKSLPFAMKEVKPELVAGKSDWELLNMPTKEIMDLL
ESAEDEIDEIKAHSARSGKHLQAIGKWLVPQTKHYSWLKAADIIGIGLDQ
VIPVPVDHNYRMDINELEKIVRGLAEEQIPVLGVVGVVGSTEEGAVDSID
KIIALRDELMKDGIYYYVHVDAAYGGYGRAIFLDEDNNFIPYEDLQDVHE
EYGVFKEKKEHISREVYDAYKAIELAESVTIDPHAMGYIPYSAGGIVIQD
IRMRDVISYFIPALLGAYILEGSKAGATAASVWAAHHVLPLNVAGYGKLI
GASIEGSHHFYNFLNDLTFKVGDKEIEVHTLTHPDFNMVDYVFKEKGNDD
LVAMNKLNHDVYDYASYVKGNIYNNEFITSHTDFAIPDYGNSPLKFVNSL
GFSDEEWNRAGKVTVLRAAVMTPYMNDKEEFDVYAPKIQAALQEKLEQIY
D
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7cwz Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7cwz Crystal structure of a tyrosine decarboxylase from Enterococcus faecalis K392A mutant in complex with the cofactor PLP and L-dopa
Resolution2.97 Å
Binding residue
(original residue number in PDB)		H526 H548 D550
Binding residue
(residue number reindexed from 1)		H509 H531 D533
Annotation score1
Enzymatic activity
Enzyme Commision number 4.1.1.-
4.1.1.25: tyrosine decarboxylase.
Gene Ontology
Molecular Function
GO:0004058 aromatic-L-amino-acid decarboxylase activity
GO:0004837 tyrosine decarboxylase activity
GO:0016829 lyase activity
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0036468 L-dopa decarboxylase activity
Biological Process
GO:0019752 carboxylic acid metabolic process
GO:1903184 L-dopa metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7cwz, PDBe:7cwz, PDBj:7cwz
PDBsum7cwz
PubMed
UniProtQ838D6|TYRDC_ENTFA L-tyrosine decarboxylase (Gene Name=tdc)

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