Structure of PDB 7cru Chain A Binding Site BS01

Receptor Information
>7cru Chain A (length=428) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFV
SFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPH
AHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGY
LRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAI
SYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTD
EQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVN
HGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPL
MNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEA
LQNHENESVYKASLSLIEKYFSEGYTFQ
Ligand information
>7cru Chain B (length=20) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
FGKRPAEDMEEEQAFKRSRN
Receptor-Ligand Complex Structure
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PDB7cru Nuclear import receptors and hnRNPK mediates nuclear import and stress granule localization of SIRLOIN.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		S105 W142 N146 S149 G150 Q181 W184 N188 D192 N228 W231 R238 D270 W273 R315 V321 T328 K348 N350 W357 N361 E396 W399 T402 S406 D442
Binding residue
(residue number reindexed from 1)		S30 W67 N71 S74 G75 Q106 W109 N113 D117 N153 W156 R163 D195 W198 R240 V246 T253 K273 N275 W282 N286 E321 W324 T327 S331 D367
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cru, PDBe:7cru, PDBj:7cru
PDBsum7cru
PubMed34689235
UniProtP52292|IMA1_HUMAN Importin subunit alpha-1 (Gene Name=KPNA2)

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