Structure of PDB 7co6 Chain A Binding Site BS01

Receptor Information

>7co6 Chain A (length=332) Species: 9606 (Homo sapiens)

MPAYACQRPTPLTHHNTGLSEALEILAEAAGFEGSEGRLLTFCRAASVLK
ALPSPVTTLSQLQGLPHFGEHSSRVVQELLEHGVCEEVERVRRSERYQTM
KLFTQIFGVGVKTADRWYREGLRTLDDLREQPQKLTQQQKAGLQHHQDLS
TPVLRSDVDALQQVVEEAVGQALPGATVTLTGGFRRGKLQGHDVDFLITH
PKEGQEAGLLPRVMCRLQDQGLILYHQHQHSMDAFERSFCIFRLPQPGSW
KAVRVDLVVAPVSQFPFALLGWTGSKLFQRELRRFSRKEKGLWLNSHGLF
DPEQKTFFQAASEEDIFRHLGLEYLPPEQRNA

Ligand information

>7co6 Chain T (length=9)

cggcttacg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7co6 Mechanism of genome instability mediated by human DNA polymerase mu misincorporation.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): L177 F385 E386 R387 K438 Q441 R442 R445 R449 K450 L456 N457 H459
• Binding residue (residue number reindexed from 1): L40 F235 E236 R237 K276 Q279 R280 R283 R287 K288 L294 N295 H297

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0005515 protein binding
• GO:0016779 nucleotidyltransferase activity
• GO:0034061 DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006281 DNA repair
• GO:0006303 double-strand break repair via nonhomologous end joining
• GO:0006310 DNA recombination
• GO:0071897 DNA biosynthetic process

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm

External links

• PDB: RCSB:7co6, PDBe:7co6, PDBj:7co6
• PDBsum: 7co6
• PubMed: 34145298
• UniProt: Q9NP87|DPOLM_HUMAN DNA-directed DNA/RNA polymerase mu (Gene Name=POLM)