Structure of PDB 7chi Chain A Binding Site BS01

Receptor Information

>7chi Chain A (length=220) Species: 3702 (Arabidopsis thaliana)

PYFIQRLFNTCKSSLSPNGPVSEEALDKVRNVLEKIKPSDVGLEQEAQLV
RLPAIKYLQLHECDSFSIGIFCMPPGSIIPLHNHPGMTVLSKLVYGSMHV
KSYDWAEPDQLQARPAKLVKDIDMTSPSPATTLYPTTGGNIHCFKAITHC
AIFDILSPPYSSTHGRHCNYFRKSPMLDLPGEIEVMNGEVISNVTWLEEY
QPPDNFVIWRVPYRGPVIRK

Ligand information

• Ligand ID: FE
• InChI: InChI=1S/Fe/q+3
• InChIKey: VTLYFUHAOXGGBS-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Fe+3]
• Formula: Fe
• Name: FE (III) ION
• DrugBank: DB13949
• PDB chain: 7chi Chain A Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7chi Molecular basis for cysteine oxidation by plant cysteine oxidases from Arabidopsis thaliana.
• Resolution: 2.502 Å
• Binding residue (original residue number in PDB): H98 H100 H164
• Binding residue (residue number reindexed from 1): H82 H84 H142
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.13.11.20: cysteine dioxygenase.

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0016491 oxidoreductase activity
• GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
• GO:0017172 cysteine dioxygenase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0018171 peptidyl-cysteine oxidation
• GO:0070483 detection of hypoxia
• GO:0071456 cellular response to hypoxia

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:7chi, PDBe:7chi, PDBj:7chi
• PDBsum: 7chi
• PubMed: 33207269
• UniProt: Q9LXT4|PCO5_ARATH Plant cysteine oxidase 5 (Gene Name=PCO5)