Structure of PDB 7cgf Chain A Binding Site BS01

Receptor Information

>7cgf Chain A (length=343) Species: 6239 (Caenorhabditis elegans)

DDLLTRYRANPAMMKNLKLSDIRGALLKFAKDQVGSRFIQQELASSKDRF
EKDSIFDEVVSNADELVDDIFGNYVVQKFFEYGEERHWARLVDAIIDRVP
EYAFQMYACRVLQKALEKINEPLQIKILSQIRHVIHRCMKDQNGCRVVQK
AIEKVSPQYVQFIVDTLLESSNTIYEMSVDPYGCRVVQRCLEHCSPSQTK
PVIGQIHKRFDEIANNQYGNYVVQHVIEHGSEEDRMVIVTRVSNNLFEFA
THKYSSNVIEKCLEQGAVYHKSMIVGAACHHSVPIVVQMMKDQYANYVVQ
KMFDQVTSEQRRELILTVRPHIPVLRQFPHGKHILAKLEKYFQ

Ligand information

>7cgf Chain B (length=8)

uguagaua

........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7cgf Structural recognition of the mRNA 3' UTR by PUF-8 restricts the lifespan of C. elegans.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): Q206 R210 Q213 N246 Y247 Y280 R283 Q286 Q315 N316 R319 Y355 R358 Q361 N393 Y394 K426 Y427 S429 N430 E433 N472 Y473 H506 H509 K513
• Binding residue (residue number reindexed from 1): Q33 R37 Q40 N73 Y74 Y107 R110 Q113 Q142 N143 R146 Y182 R185 Q188 N220 Y221 K253 Y254 S256 N257 E260 N296 Y297 H330 H333 K337

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

External links

• PDB: RCSB:7cgf, PDBe:7cgf, PDBj:7cgf
• PDBsum: 7cgf
• PubMed: 34478557
• UniProt: Q09487