Structure of PDB 7cdw Chain A Binding Site BS01

Receptor Information
>7cdw Chain A (length=683) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKDVLTDLSRVRNFGIMAHIDAGKTTTTERILYYTGINYKIGEVHDERGI
TITSAATTTFWKDNQLNIIDTPGTVEVERNLRVLDGAVAVFDGKEGVEPQ
SEQVWRQADKYDVPRICFVNKMDKIGADFYFSVRTMGERLGANAVPIQLP
VGAEADFEGVVDLVEMNAKVWRGETKLGETYDTVEIPADLAEQAEEYRTK
LLEVVAESDEHLLEKYLGGEELTVDEIKGAIRKLTIASEIYPVLCGSAFK
NKGVQPMLDAVVDYLPSPLDVPPAIGHAPAKEDEEVVRKATTDEPFAALA
FKIATHPFFGKLTYIRVYSGTVESGSQVINATKGKKERLGKLFQMHSNKE
NPVDRASAGHIYAVIGLKDTTTGDTLSDPNQQIVLESMTFPDPVIEVAIE
PKTKSDQEKLSLSIQKLAEEDPTFKVHLDSETGQTVIGGMGELHLDILVD
RMRREFKVEANVGKPQVAYKETIKRLVQNVEYTHKKQTGGSGQFAKVIIN
LEPFTGEEGATYEFESKVTGGRIPREYIPSVDAGAQDAMQYGVLAGYPLV
NLKVTLLDGAYHEVDSSEMAFKIAGSQVLKKAAALAQPVILEPIMAVEVT
TPEDYMGDVIGDLNSRRGQIQAMEERAGARVVRAHVPLSEMFGYVGDLRS
KTQGRANYSMVFDSYSEVPANVSKEIIAKATGE
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain7cdw Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7cdw Crystal Structure of Mycobacterium tuberculosis Elongation Factor G1.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D23 G25 K26 T27 T28 N138 K139 D141 K142 S265 F267
Binding residue
(residue number reindexed from 1)		D21 G23 K24 T25 T26 N120 K121 D123 K124 S247 F249
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0032790 ribosome disassembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7cdw, PDBe:7cdw, PDBj:7cdw
PDBsum7cdw
PubMed34540889
UniProtP9WNM7|EFG_MYCTU Elongation factor G (Gene Name=fusA)

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