Structure of PDB 7c8k Chain A Binding Site BS01

Receptor Information
>7c8k Chain A (length=596) Species: 196889 (Rhinolophus macrotis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STTEDEAKKFLDKFNSKAEDLSYESSLASWDYNTNISDENVQKMDEAGAK
WSAFYEEQSKLAKNYPLEEIQNDTVKRQLQILQQSGSPVLSEDKSKRLNS
ILNAMSTIYSTGKVCKPNNPQECLLLEPGLDNIMGTSKDYNERLWAWEGW
RAEVGKQLRPLYEEYVVLKNEMARGYHYEDYGDYWRRDYETEESSGPGYS
RDQLMKDVDRIFTEIKPLYEHLHAYVRAKLMDTYPLHISPTGCLPAHLLG
DMWGRFWTNLYPLTVPFGQKPNIDVTDAMLNQGWDANRIFKEAEKFFVSV
SLPKMTEGFWNKSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMCTKVTMED
FLTAHHEMGHIQYDMAYASQPYLLRNGANEGFHEAVGEVMSLSVATPKHL
KTMGLLSPDFREDDETEINFLLKQALNIVGTLPFTYMLEKWRWMVFKGEI
PKEEWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVANDYSFIRYYTR
TIFEFQFHEALCRIAQHNGPLHKCDISNSTDAGKKLHQMLSVGKSQAWTK
TLEDIVDSRNMDVGPLLRYFKPLYTWLQEQNRKSYVGWNTDWSPYA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7c8k Chain A Residue 705 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7c8k Cross-species recognition of SARS-CoV-2 to bat ACE2.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H374 H378 E402
Binding residue
(residue number reindexed from 1)		H356 H360 E384
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H345 P346 H374 E375 H378 E402 H505 Y515
Catalytic site (residue number reindexed from 1) H327 P328 H356 E357 H360 E384 H487 Y497
Enzyme Commision number 3.4.-.-
3.4.17.23: angiotensin-converting enzyme 2.
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c8k, PDBe:7c8k, PDBj:7c8k
PDBsum7c8k
PubMed33335073
UniProtE2DHI3

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