Structure of PDB 7c8j Chain A Binding Site BS01

Receptor Information
>7c8j Chain A (length=707) Species: 196889 (Rhinolophus macrotis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTEDEAKKFLDKFNSKAEDLSYESSLASWDYNTNISDENVQKMDEAGAKW
SAFYEEQSKLAKNYPLEEIQNDTVKRQLQILQQSGSPVLSEDKSKRLNSI
LNAMSTIYSTGKVCKPNNPQECLLLEPGLDNIMGTSKDYNERLWAWEGWR
AEVGKQLRPLYEEYVVLKNEMARGYHYEDYGDYWRRDYETEESSGPGYSR
DQLMKDVDRIFTEIKPLYEHLHAYVRAKLMDTYPLHISPTGCLPAHLLGD
MWGRFWTNLYPLTVPFGQKPNIDVTDAMLNQGWDANRIFKEAEKFFVSVS
LPKMTEGFWNKSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMCTKVTMEDF
LTAHHEMGHIQYDMAYASQPYLLRNGANEGFHEAVGEVMSLSVATPKHLK
TMGLLSPDFREDDETEINFLLKQALNIVGTLPFTYMLEKWRWMVFKGEIP
KEEWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVANDYSFIRYYTRT
IFEFQFHEALCRIAQHNGPLHKCDISNSTDAGKKLHQMLSVGKSQAWTKT
LEDIVDSRNMDVGPLLRYFKPLYTWLQEQNRKSYVGWNTDWSPYADQSIK
VWISLKSALGEKAYEWNDNEMYLFRSSVAYAMREYFLKTKNQTILFGDEN
VWVSNLKPRISFNFHVTSPGNVSDIIPRPEVEGAIRMSRSRINDAFRLDD
NSLEFLG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7c8j Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7c8j Cross-species recognition of SARS-CoV-2 to bat ACE2.
Resolution3.18 Å
Binding residue
(original residue number in PDB)		H374 H378 E402
Binding residue
(residue number reindexed from 1)		H355 H359 E383
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H345 P346 H374 E375 H378 E402 H505 Y515
Catalytic site (residue number reindexed from 1) H326 P327 H355 E356 H359 E383 H486 Y496
Enzyme Commision number 3.4.-.-
3.4.17.23: angiotensin-converting enzyme 2.
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0042995 cell projection

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7c8j, PDBe:7c8j, PDBj:7c8j
PDBsum7c8j
PubMed33335073
UniProtE2DHI3

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