Structure of PDB 7c7l Chain A Binding Site BS01

Receptor Information
>7c7l Chain A (length=503) Species: 115547 (uncultured archaeon) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALKEACSKHLKVTTQ
VERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIY
NQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELFKNAAIASGLR
SKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSD
FIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNK
GWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKIGEKSAWMLNLSIDVPKI
DKGVDPSIIGGIAVGVKSPLVCAINNAFSRYSISDNDLFHFNKKMFARRR
ILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIK
NKVGTVQMENLESMKRKEDSYFNIRLWPYAEMQNKIEFKLKQYGIEIRKV
APNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNADYNAALNISNP
KLK
Ligand information
>7c7l Chain C (length=116) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccgcuucaccaugagugaaggugggcugcuugcaucagccuaaugucgag
aagugcuuucuucggaaaguaacccucgaaacaaaaggaaugcaacggaa
auuaggugcgcuuggc
...<<<<<<<..>.>>>>>>...(((((.<<<<<<))))).....<<<<<
..<<<<<<<<<..>>>>>>>.>>.>>>>>..........>>>>>>.....
................
Receptor-Ligand Complex Structure
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PDB7c7l Structure of the miniature type V-F CRISPR-Cas effector enzyme.
Resolution3.3 Å
Binding residue
(original residue number in PDB)
T7 K8 T9 K11 R13 R16 K31 R66 N67 C72 K76 Y82 W95 S99 Y113 K165 N169 S180 P183 T185 P191 S255 T256 Q257 R258 R259 T271 E272 E289 K291 K299 N305 R363 L366 K367 K368 K372 R373 A374 G375 H376 G377 A378 K379 K381 L382 K391 R394 K397 K398 E401 C405 F454 K455
Binding residue
(residue number reindexed from 1)
T5 K6 T7 K9 R11 R14 K29 R53 N54 C59 K63 Y69 W82 S86 Y100 K152 N156 S167 P170 T172 P178 S242 T243 Q244 R245 R246 T258 E259 E276 K278 K286 N292 R350 L353 K354 K355 K359 R360 A361 G362 H363 G364 A365 K366 K368 L369 K378 R381 K384 K385 E388 C392 F438 K439
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function

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Biological Process
External links
PDB RCSB:7c7l, PDBe:7c7l, PDBj:7c7l
PDBsum7c7l
PubMed33333018
UniProtA0A482D308|CS12F_UNCAX CRISPR-associated endodeoxyribonuclease Cas12f1 (Gene Name=cas12f)

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