Structure of PDB 7by1 Chain A Binding Site BS01

Receptor Information
>7by1 Chain A (length=287) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQRKAQVRGLPRAKKLEKLGVFSACKANETCKCNGWKNPKPPPAANLSEL
CRSCEHPLADHVSHLENVSEDEINRLLGMVVDVENLFMSVHKEEDTDTKQ
VYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQYKFSHL
APRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQSEDVATYKVNYTRWL
CYCHVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVP
EKRTLILTHFPKFLSMLEEEIYGANSPIWESGFTMPP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7by1 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7by1 Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C107 C113 C145 H147
Binding residue
(residue number reindexed from 1)		C25 C31 C54 H56
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7by1, PDBe:7by1, PDBj:7by1
PDBsum7by1
PubMed32820047
UniProtQ9JHD2|KAT2A_MOUSE Histone acetyltransferase KAT2A (Gene Name=Kat2a)

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