Structure of PDB 7bw9 Chain A Binding Site BS01

Receptor Information

>7bw9 Chain A (length=280) Species: 5759 (Entamoeba histolytica)

MSSLLQQTSQLLVQSYQSDNIAFKSTKQFPEKKSFLELELIQKILFPDFF
TRRDKRTFNNVLERLSLLVYHIQNSIEAYYNQQLAEKCITALLSQFVTIR
ELVKQDIIAAYTGDPAASSLAMIIRSYPGIHVMMIQRVAHILYMNGDIEY
SRELMENIHSVTGIDIHPGTSIGNHFFIDHGVGVVIGETAVIGNWCRVYQ
SVTLGAMSFKGNKRHPTIGDFVVIGAGAKVLGNITIGSNVKIGANCWITQ
NIDQDQIVFISEHPSQITKENLSWVNSPEL

Ligand information

• Ligand ID: CYS
• InChI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1
• InChIKey: XUJNEKJLAYXESH-REOHCLBHSA-N
• SMILES:
  CACTVS 3.341: N[CH](CS)C(O)=O
  OpenEye OEToolkits 1.5.0: C([C@@H](C(=O)O)N)S
  CACTVS 3.341: N[C@@H](CS)C(O)=O
  ACDLabs 10.04: O=C(O)C(N)CS
  OpenEye OEToolkits 1.5.0: C(C(C(=O)O)N)S
• Formula: C3 H7 N O2 S
• Name: CYSTEINE
• ChEMBL: CHEMBL863
• DrugBank: DB00151
• ZINC: ZINC000000895042
• PDB chain: 7bw9 Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7bw9 Crystal structure of Serine acetyltransferase isoform 3 in complex with cysteine from Entamoeba histolytica
• Resolution: 2.131 Å
• Binding residue (original residue number in PDB): D114 P115 D179 H180
• Binding residue (residue number reindexed from 1): D114 P115 D179 H180
• Annotation score: 2

Enzymatic activity

• Enzyme Commision number: 2.3.1.30: serine O-acetyltransferase.

Gene Ontology

Molecular Function

• GO:0009001 serine O-acetyltransferase activity
• GO:0016746 acyltransferase activity

Biological Process

• GO:0008652 amino acid biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:7bw9, PDBe:7bw9, PDBj:7bw9
• PDBsum: 7bw9
• UniProt: Q401L4