Structure of PDB 7bv5 Chain A Binding Site BS01

Receptor Information
>7bv5 Chain A (length=234) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADLQHIKHMRTAVRLARYALDHDETPVACIFVHTPTGQVMAYGMNDTNKS
LTGVAHAEFMGIDQIKAMLGSRGVVDVFKDITLYVTVEPCIMCASALKQL
DIGKVVFGCGNERFGGNGTVLSVNHDTCTLVPKNNSAAGYESIPGILRKE
AIMLLRYFYVRQNERAPNTFPPMEWSKYLNEEAFIETFGDDYRTCFANKV
DLSSNSVDWDLIDSHQDNIIQELEEQCKMFKFNV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7bv5 Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7bv5 Crystal structure of the yeast heterodimeric ADAT2/3 deaminase.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		H54 C88 C91
Binding residue
(residue number reindexed from 1)		H56 C90 C93
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.33: tRNA(adenine(34)) deaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008251 tRNA-specific adenosine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0019239 deaminase activity
GO:0046872 metal ion binding
GO:0052717 tRNA-specific adenosine-34 deaminase activity
Biological Process
GO:0002100 tRNA wobble adenosine to inosine editing
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0034654 nucleobase-containing compound biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0052718 tRNA-specific adenosine-34 deaminase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bv5, PDBe:7bv5, PDBj:7bv5
PDBsum7bv5
PubMed33272269
UniProtP47058|TAD2_YEAST tRNA-specific adenosine deaminase subunit TAD2 (Gene Name=TAD2)

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