Structure of PDB 7btq Chain A Binding Site BS01

Receptor Information
>7btq Chain A (length=474) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AELHRQIWQIANDVRGSVDGWDFKQYVLGALFYRFISENFSSYIEAGTDD
IKDDAIKTKGYFIYPSQLFCNVAAKANTNDRLNADLNSIFVAIESSAYGY
PSEADIKGLFADFDTTSNRLGNTVKDKNARLAAVLKGVEGLKLGIDLFGD
AYEFLISNYAAEFFTPQHVSKLIAQLAMHGQTHVNKIYDPAAGSGSLLLQ
AKKQFDNHIIEEGFFGQEINHTTYNLARMNMFLHNINYDKFDIKLGNTLT
EPHFRDEKPFDAIVSNPPYSVKWIGSDDPTLINDERFAPAGVLAPKSKAD
FAFVLHALNYLSAKGRAAIVCFPGIFYRGGAEQKIRQYLVDNNYVETVIS
LAPNLFFGTTIAVNILVLSKHKTDTNVQFIDASELFKKETNNNILTDAHI
EQIMQVFASKEDVAHLAKSVAFETVVANDYNLSVSSYVEAKDNREIIDIA
ELNAELKTTVSKIDQLRKDIDAIV
Ligand information
>7btq Chain B (length=44) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccaaaaatctaaaatcgaattcgaggtcgaaaaagagaaaaacc
Receptor-Ligand Complex Structure
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PDB7btq Structural insights into assembly, operation and inhibition of a type I restriction-modification system.
Resolution4.54 Å
Binding residue
(original residue number in PDB)		F199 Y305 Y363 R364 T395
Binding residue
(residue number reindexed from 1)		F163 Y269 Y327 R328 T359
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0009307 DNA restriction-modification system
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7btq, PDBe:7btq, PDBj:7btq
PDBsum7btq
PubMed32483229
UniProtP10484|T1M1_ECOLX Type I restriction enzyme EcoR124I/EcoR124II methylase subunit (Gene Name=hsdM)

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