Structure of PDB 7brk Chain A Binding Site BS01

Receptor Information
>7brk Chain A (length=426) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVL
GSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHW
RVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQA
LVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLL
RAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKS
AQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLL
ADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQ
RMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQE
LMAVSEHKLYWPLGYPPPDVPKCGFD
Ligand information
>7brk Chain L (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SSCFGGRMDRIGAQSGLGCNSFR
Receptor-Ligand Complex Structure
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PDB7brk Structural insight into hormone-recognition and transmembrane signaling by the atrial natriuretic peptide receptor
Resolution2.85 Å
Binding residue
(original residue number in PDB)		D62 Y88 R95 G113 F165 V168 E169 M173 H185
Binding residue
(residue number reindexed from 1)		D62 Y88 R95 G113 F165 V168 E169 M173 H185
Enzymatic activity
Enzyme Commision number 4.6.1.2: guanylate cyclase.
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:7brk, PDBe:7brk, PDBj:7brk
PDBsum7brk
PubMed
UniProtP18910|ANPRA_RAT Atrial natriuretic peptide receptor 1 (Gene Name=Npr1)

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