Structure of PDB 7bri Chain A Binding Site BS01

Receptor Information
>7bri Chain A (length=426) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVL
GSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHW
RVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQA
LVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLL
RAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKS
AQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLL
ADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQ
RMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQE
LMAVSEHKLYWPLGYPPPDVPKCGFD
Ligand information
>7bri Chain L (length=29) Species: 8618 (Dendroaspis angusticeps) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EVKYDPCFGHKIDRINHVSNLGCPSLRDP
Receptor-Ligand Complex Structure
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PDB7bri Structural insight into hormone-recognition and transmembrane signaling by the atrial natriuretic peptide receptor
Resolution2.45 Å
Binding residue
(original residue number in PDB)		D62 Y88 R95 E119 Y154 L158 R162 F165 F166 E169 M173 H185 E187 V189
Binding residue
(residue number reindexed from 1)		D62 Y88 R95 E119 Y154 L158 R162 F165 F166 E169 M173 H185 E187 V189
Enzymatic activity
Enzyme Commision number 4.6.1.2: guanylate cyclase.
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:7bri, PDBe:7bri, PDBj:7bri
PDBsum7bri
PubMed
UniProtP18910|ANPRA_RAT Atrial natriuretic peptide receptor 1 (Gene Name=Npr1)

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