Structure of PDB 7bre Chain A Binding Site BS01

Receptor Information
>7bre Chain A (length=179) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVD
EMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSS
GYGQGDVLGFYINLPEDRGSSEIIFYKNGVNQGVAYKDIFEGVYFPAISL
YKSCTVSINFGPCFKYPPKDLTYRPMSDM
Ligand information
>7bre Chain C (length=20) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
FKELDENVEYEERESEFDIE
Receptor-Ligand Complex Structure
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PDB7bre Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases.
Resolution2.803 Å
Binding residue
(original residue number in PDB)		G312 Y313 R343 P356 R367 S377 Y475
Binding residue
(residue number reindexed from 1)		G28 Y29 R59 P72 R83 S93 Y151
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Cellular Component
GO:0048188 Set1C/COMPASS complex

View graph for
Cellular Component
External links
PDB RCSB:7bre, PDBe:7bre, PDBj:7bre
PDBsum7bre
PubMed32697937
UniProtQ9UBL3|ASH2L_HUMAN Set1/Ash2 histone methyltransferase complex subunit ASH2 (Gene Name=ASH2L)

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