Structure of PDB 7bq2 Chain A Binding Site BS01

Receptor Information

>7bq2 Chain A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ADLKSLAKRIYEAYLKNFNMNKVKARVILSGPPFVIHDMETLCMAEKTLV
AKLVANKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL
KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF
DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLR
LHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPL
LQEIYRDMY

Ligand information

>7bq2 Chain B (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RHKILHRLLQ

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7bq2 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
Resolution	1.52 Å
Binding residue (original residue number in PDB)	T288 K292 N303 Q305 V306 L309 K310 L459 E462
Binding residue (residue number reindexed from 1)	T79 K83 N94 Q96 V97 L100 K101 L250 E253

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:7bq2, PDBe:7bq2, PDBj:7bq2
PDBsum	7bq2
PubMed	33205029
UniProt	Q07869\|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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