Structure of PDB 7boc Chain A Binding Site BS01

Receptor Information
>7boc Chain A (length=211) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LCMPVFHPRFKDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGA
YLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRY
SGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAA
ILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCS
YLQYLEYLSQN
Ligand information
Receptor-Ligand Complex Structure
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PDB7boc Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5-MEP50 Complex.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		L237 N239 K240 K241 F243 K248 Q282 Y283 Y286
Binding residue
(residue number reindexed from 1)		L158 N160 K161 K162 F164 K169 Q203 Y204 Y207
Enzymatic activity
Enzyme Commision number 2.1.1.320: type II protein arginine methyltransferase.
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7boc, PDBe:7boc, PDBj:7boc
PDBsum7boc
PubMed33624332
UniProtO14744|ANM5_HUMAN Protein arginine N-methyltransferase 5 (Gene Name=PRMT5)

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