Structure of PDB 7bkq Chain A Binding Site BS01

Receptor Information
>7bkq Chain A (length=640) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASE
SGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVK
SYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYN
NIMRRYLKQKLRNNDLKKQNKPAIPLPQILGLTASPGVGAAKKQSEAEKH
ILNICANLDAFTIKTVKENLGQLKHQIKKFVIANPFKEKLLEIMASIQTY
CQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQIN
DTIRMIDAYSHLETFYTDEKEKKFAVLNDKLDETDEFLMNLFFDNKKMLK
KLAENPEKLIKLRNTILEQFTRSSSRGIIFTKTRQSTYALSQWIMENAKF
AEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEINLLIATTVAEE
GLDIKECNIVIRYGLSTYVLVTEREIVNDFREKMMYKAINRVQNMKPEEY
AHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSMLVCSGEN
IHVIEKMHHVNMTPEFKGLYIVRENKNGEIICKCGQAWGTMMVHKGLDLP
CLKIRNFVVNFKNNSPKKQYKKWVELPIRFPDLDYSEYCL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7bkq MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		K451 E452 Q581 T767 T769 H927 K1002
Binding residue
(residue number reindexed from 1)		K145 E146 Q266 T423 T425 H558 K622
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:7bkq, PDBe:7bkq, PDBj:7bkq
PDBsum7bkq
PubMed34795277
UniProtQ8R5F7|IFIH1_MOUSE Interferon-induced helicase C domain-containing protein 1 (Gene Name=Ifih1)

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