Structure of PDB 7bgt Chain A Binding Site BS01

Receptor Information

>7bgt Chain A (length=108) Species: 11855 (Mason-Pfizer monkey virus)

WVQPITAQKPSLTLWLDDKMFTGLINTGADVTIIKLEDWPPNWPITDTLT
NLRGIGQSNNPKQSSKYLTWRDKENNSGLIKPFVIPNLPVNLWGRDLLSQ
MKIMMASP

Ligand information

>7bgt Chain F (length=7) Species: 32630 (synthetic construct)

PYVYAMH

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7bgt Crystal structures of inhibitor complexes of M-PMV protease with visible flap loops.
• Resolution: 1.93 Å
• Binding residue (original residue number in PDB): L24 N26 G28 A29 D30 L52 R53 P89 L92
• Binding residue (residue number reindexed from 1): L24 N26 G28 A29 D30 L52 R53 P89 L92

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.26.4: ribonuclease H.
  3.4.23.-
  3.6.1.23: dUTP diphosphatase.

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:7bgt, PDBe:7bgt, PDBj:7bgt
• PDBsum: 7bgt
• PubMed: 33786913
• UniProt: P07572|POL_MPMV Gag-Pro-Pol polyprotein (Gene Name=gag-pro-pol)