Structure of PDB 7b4d Chain A Binding Site BS01

Receptor Information
>7b4d Chain A (length=197) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPV
QLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCDGLAPPQHLIR
VEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNRSCMGGM
NRRPILTIITLEDSSGNLLGRNSFEVCVCACPGRDRRTEEENLRKKG
Ligand information
Receptor-Ligand Complex Structure
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PDB7b4d Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Resolution1.85 Å
Binding residue
(original residue number in PDB)		R240 S241 A276 C277 R280
Binding residue
(residue number reindexed from 1)		R144 S145 A180 C181 R184
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7b4d, PDBe:7b4d, PDBj:7b4d
PDBsum7b4d
PubMed34862374
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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