Structure of PDB 7b44 Chain A Binding Site BS01

Receptor Information
>7b44 Chain A (length=282) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKK
IHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLGSPLVVL
PYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAA
RNCMLDEKFTVKVADFGLARDMYDKEYYSVHPVKWMALESLQTQKFTTKS
DVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYE
VMLKCWHPKAEMRPSFSELVSRISAIFSTFIG
Ligand information
Ligand IDSVT
InChIInChI=1S/C8H8N2O/c1-11-7-2-3-8-6(4-7)5-9-10-8/h2-5H,1H3,(H,9,10)
InChIKeyGZWWDKIVVTXLFL-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7COc1ccc2c(c1)cn[nH]2
CACTVS 3.385COc1ccc2[nH]ncc2c1
FormulaC8 H8 N2 O
Name5-methoxy-1~{H}-indazole
ChEMBLCHEMBL15739
DrugBank
ZINCZINC000014983627
PDB chain7b44 Chain A Residue 1401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7b44 Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Resolution1.76 Å
Binding residue
(original residue number in PDB)		F1089 A1108 P1158 Y1159 M1160 M1211
Binding residue
(residue number reindexed from 1)		F35 A54 P101 Y102 M103 M154
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D1204 R1208 N1209 D1222
Catalytic site (residue number reindexed from 1) D147 R151 N152 D165
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7b44, PDBe:7b44, PDBj:7b44
PDBsum7b44
PubMed33488978
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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