Structure of PDB 7b3t Chain A Binding Site BS01

Receptor Information
>7b3t Chain A (length=261) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKS
LQFLTEGIIMKDFSHPNVLSLLGICLSPLVVLPYMKHGDLRNFIRNETHN
PTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGL
ARDMYDKEYYSLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPP
YPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSEL
VSRISAIFSTF
Ligand information
Ligand IDSVK
InChIInChI=1S/C14H12N2/c1-2-5-11(6-3-1)9-12-10-16-14-13(12)7-4-8-15-14/h1-8,10H,9H2,(H,15,16)
InChIKeyGZMFYYLEABBTHR-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7c1ccc(cc1)Cc2c[nH]c3c2cccn3
CACTVS 3.385C(c1ccccc1)c2c[nH]c3ncccc23
FormulaC14 H12 N2
Name3-(phenylmethyl)-1~{H}-pyrrolo[2,3-b]pyridine
ChEMBLCHEMBL4744343
DrugBank
ZINCZINC000079025620
PDB chain7b3t Chain A Residue 1401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7b3t Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Resolution2.23 Å
Binding residue
(original residue number in PDB)		I1084 F1089 V1092 A1108 L1157 P1158 Y1159 M1160 M1211 A1226 M1229
Binding residue
(residue number reindexed from 1)		I23 F28 V31 A47 L82 P83 Y84 M85 M136 A151 M154
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D1204 R1208 N1209 D1222
Catalytic site (residue number reindexed from 1) D129 R133 N134 D147
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7b3t, PDBe:7b3t, PDBj:7b3t
PDBsum7b3t
PubMed33488978
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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