Structure of PDB 7b2k Chain A Binding Site BS01

Receptor Information
>7b2k Chain A (length=282) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TARTAPAGGEVRHLKMYAEKLADGQMGYGFEKGKASVPGPLIEVNEGDTL
HIEFTNTMDVRASLHVHGLDYEISSDGTAMNKSDVEPGGTRTYTWRTHKP
GRRDDGTWRPGSAGYWHYHDHVVGTEHGTGGIRNGLYGPVIVRRKGDVLP
DATHTIVFNDMTINNRKPHTGPDFEATVGDRVEIVMITHGEYYHTFHMHG
HRWADNRTGILTGPDDPSRVIDNKITGPADSFGFQIIAGEGVGAGAWMYH
CHVQSHSDMGFVGLFLVKKPDGTIPGYEPHEH
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain7b2k Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7b2k Substitution of the Methionine Axial Ligand of the T1 Copper for the Fungal-like Phenylalanine Ligand (M298F) Causes Local Structural Perturbations that Lead to Thermal Instability and Reduced Catalytic Efficiency of the Small Laccase from Streptomyces coelicolor A3(2).
Resolution2.2 Å
Binding residue
(original residue number in PDB)		H231 C288 H293
Binding residue
(residue number reindexed from 1)		H194 C251 H256
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:7b2k, PDBe:7b2k, PDBj:7b2k
PDBsum7b2k
PubMed35224382
UniProtQ9XAL8

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